Creatinine clearance crcl 46 to 60 ml min, reduce dose 20%. Dacarbazine is available for injection in vials of 10 mgml and the recommended dose varies by indication and body weight 2 to 4. Click here for a specialized list of other renal medication dosing not listed in the alphabetical main section simple renal dosing guidelines. Dacarbazine is also used in combination with other medications to treat hodgkins lymphoma hodgkins disease. Dosing guidelines book dosing guidelines for children dosing guidelines for adults. Such patients frequently have multiple system involvement.
This book consists of a brief introductory chapter con taining a discussion of drug ther apy in patients with renal. Guidelines for chemotherapy dosage adjustment hematology. Each vial contains 100 mg of dacarbazine, or 200 mg of dacarbazine the active ingredient, anhydrous citric acid and mannitol. Dosing may need to be reduced in either clinical situation. Dacarbazine dtic alkylating agent is a longestablished treatment for metastatic melanoma, and is considered to be the standard by which other. Preexisting hepatic disease or renal impairment can cause accumulation of the drug worsening dacarbazines toxicity. Lisinopril 1020 mg daily lower dose with severe chronic kidney disease, chf or age over 80 years. Doxorubicin and dacarbazine ad regimen for soft tissue. Practitioners must not use this pgd template unless it has been authorised in section 2. Antiemetic group high delay if neutrophils dacarbazine is used to treat melanoma a type of skin cancer that has spread to other parts of your body. The renal drug handbook the ultimate prescribing guide for renal practitioners 5th edition. Uclh dosage adjustment for cytotoxics in renal impairment version 3 updated january2009 page 2 of 24 dosage adjustment for cytotoxics in renal impairment this table is a guide only. Dacarbazine for injection is reconstituted and administered intravenously ph 34.
Pediatric drugs analgesics antihypertensive and cardiovascular agents antimicrobial agents miscellaneous agents sedatives, hypnotics, and other drugs used in psychiatry. The information on dosage adjustments in renal impairment given in this book is based on cockcroftgault creatinine clearance and not egfr, since the majority. Usual dose q24h esrd crcl dose q24h monitor for cns toxicity. A catalogue record for this book is available from the british library. For less emetogenic regimens, 1 mgkg per dose may be adequate. Dacarbazine is licensed for use as a single agent for metastatic melanoma in doses of 24. An alternate recommended dosage is 250 mgsquare meter body surfaceday iv for 5 days. Dose reduction and close monitoring of hepatic and bone marrow function may be required. Specific guidelines for dosage adjustments in renal impairment not available, it appears that no dosage adjustments are needed bendamustine bilirubin 1. The renal drug handbook 5th edition medicina interna.
Bennetts drug prescribing in renal failure has been the best pocket book for drug prescribing in patients with renal insufficiency and dialysis since the first edition in 1987. Efficacy of combined axitinib with dacarbazine in a b16f1. Dacarbazine dacarbazine dose, indications, adverse. Adult drugs analgesics antihypertensive and cardiovascular agents antimicrobial agents miscellaneous agents sedatives, hypnotics, and other drugs used in. The pharmacists will automatically adjust the doses of any of the antimicrobials included in the protocol according to the estimated creatinine clearance generally using the cockroftgault equation for patients. The drug can also be given in a dose of 850 mgm 2 by intravenous infusion at 3. Public users are able to search the site and view the abstracts for each book. Seyffarts directory of drug dosage in kidney disease authors. Munar, pharmd, bcps, and harleen singh, pharmd oregon state university college of pharmacy, portland, oregon. Drug dosing in chronic kidney disease family practice notebook. This medication is given by injection into a vein by a health care professional. Drug dosing in chronic kidney disease oxford medicine. Renal dosage adjustment guidelines for antimicrobials. Monitor complete blood counts before initiating therapy, prior to each new cycle, and as clinically indicated.
Malignant melanoma the recommended dosage is 2 to 4. Dacarbazine dosage the recommended dacarbazine dosage will be different for each person, depending on his or her weight, the reason the medicine is being used, and a number of other factors. Cisplatin can cause severe bone marrow suppression with fatalities due to infection. Dosing guidelines for adults, fifth edition 97819305761 and a great selection of similar new, used and collectible books. Seyffarts directory of drug dosage in kidney disease dustri verlag. Renal drug handbook 3rd edition general intensive care unit. Dacarbazine dtic chemotherapy uses, dose, interactions. As the field moves forward so also do the therapeutic opportunities, and pitfalls. The initial two doses should be 2 mgkg if highly emetogenic drugs such as cisplatin or dacarbazine are used alone or in combination. Dacarbazine is given by intravenous infusion typically for five to ten days in cycles of every 3 to 4 weeks. Dose reduction may be required in combined renal and hepatic impairment. The incidence of cutaneous melanoma is annually increasing worldwide. Clinical course of haemodialysis patients with malignancies and dose adjusted chemotherapy.
Dacarbazine is contraindicated in patients who have demonstrated a hypersensitivity to it in the past and in patients with hepatic andor renal insufficiency. Drug dosing adjustments in patients with chronic kidney disease myrna y. Dacarbazine for injection, usp is reconstituted and administered intravenously ph 34. Dticdome dacarbazine has been shown to be teratogenic in rats when given in doses 20 times the human daily dose on day 12 of gestation. Drug dosage in renal insufficiency has become an toxication. Dosing guidelines for adults and children, 5th, american college of physicians, 2007. Dacarbazine is metabolized via hepatic pathways, so dosage adjustments may be necessary. The authors make no claims of the accuracy of the information contained herein. For doses in excess of 10 mg, reglan injection should be diluted in 50 ml of a parenteral solution.
The recommended dose of halaven in patients with moderate to severe renal impairment creatinine clearance clcr 1549 mlmin is 1. Dosing guidelines book school of medicine university of louisville. Started in 1995, this collection now contains 6769 interlinked topic pages divided into a tree of 31 specialty books and 732 chapters. Specific pharmacologic considerations in the setting of renal insufficiency. Seyffarts directory of drug dosage in kidney disease. Dacarbazine is a structural analogue of imidazole carboxamide, a purine precursor. This prescription drug comes as an injection that is given into a vein intravenously, or by iv. Dtlc when administered in 10 times the human daily dose to male rats twice weekly for 9 weeks did not affect the male libido, although female rats mated to male rats had higher. Dosage adjustment for cytotoxics in renal impairment.
Dosing guidelines book school of medicine university of. Dtic dome dacarbazine dosing, indications, interactions. Dacarbazine moderately effective removed by dialysis in vitro and likely to be removed in vivo based on pk properties. Renal dosage adjustment guidelines for antimicrobials the pharmacists will automatically adjust the doses of any of the antimicrobials included in the protocol according to the estimated creatinine clearance generally using the cockroftgault equation for patients. Dosage and indications dacarbazine can be dosed in dogs at 200 mgm 2 as a slow iv bolus given once daily for 5 days, or once as a slow iv infusion over 2 to 8 hours at mgm 2 every 3 weeks. The information on dosage adjustments in renal impairment given in this book is based on cockcroftgault creatinine clearance and not egfr, since the majority of. The manufacturer reports no information about dose reduction for renal dysfunction. Pharmacokinetic, summary of product characteristics spc, relevant pharmaceutical company data and various references have been. The renal drug handbook the st georges hospital, adult critical. This barcode number lets you verify that youre getting exactly the right version or edition of a book. Dacarbazine mechanism, indication, contraindications. Each vial contains 200 mg of dacarbazine the active ingredient, citric acid monohydrate and mannitol.
Dacarbazine is an anticancer agent designated chemically. Special pediatric considerations are noted when applicable, otherwise adult provisions apply. The renal drug handbook has developed into an essential resource for nephrologists, specialist nurses and pharmacists engaged in the care of these patients. Anticipate a 15% increase in serum creatinine in week 1. It is given on a schedule as directed by your doctor. Cisplatin cisplatin dose, indications, adverse effects. The fifth edition of 2007 has been significantly expanded by dosage tables for children. If your institution subscribes to this resource, and you dont have a myaccess profile, please contact your librarys reference desk for information on how to. For hodgkins disease as a secondline therapy when used in combination with other agents.
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